Totalt antall sidevisninger

torsdag 1. desember 2011

North-East European, not Siberian (updated)

In earlier posts I have indicated that dimension 1 in the later MDS plots was of Sibieran origin. This I assumed based on similarities with the clustering with or without Siberians. I have now done a new review with the Siberian and conclude thats not the case. This is the plot in question I have published earlier. In the plot below dimension 1 (horisontal) I suggested to be a Siberian (left) vs European (right) dimension while dimension 2 I suggested to be an western European (bottom) and eastern European dimension (top). After new insights this may need some more modifications:

I did a new run with the current panel. I added 4 unrelated Sibierans (Ngaans and Dolgan) into the panel. This gave the following MDS plot:

Impossible to see the details here but the general impression is that Siberians is a fairly distant population. Dimension 1 here is the horisontal axis where the extreme left is Siberian while the extreme right is European. Dimension 2 appears to be an internal European dimension with the North Italians at one extreme while the The Finns appear on the other extreme suggesting the dimension is a north-south dimension. The Saamis appears to stick out somewhat from the Finns. In this image its hard to see the details so lets us zoom in.

As we can see here in detail the Italians have the lowest Siberian influence. It appears to be in a continuity all the way downward and increase more to left as we go down the vertical axis. The Scandinavians is inside partly in the Belorussian and Hungarian cluster. However from this part the Siberian influence separate into the Vologda Russians and the Lithuanians. Most Finns (with some internal variations) appears to have similar Siberian influence as the Vologda Russians.  The Saami appears to continue further left at the same downward level as part of the Finns.

However as the plot shows above the European dimension (D2) isnt more informative than showing an North-South influence. We have an additional dimension 3 and when we compare it do dimension 2 we get a very familiar MDS plot to the one seen at the top just rotated left 90 degrees:

So basically what the earlier plot showed was that dimension was a north-south axis or more preciously a south-west vs north-east genetic and geographic distribution while dimension 2 again separate it into an west and east genetic and geographic distribution or to be more precise a north-west vs south-east genetic and geographic distribution. Below dimension 1 represented geographically.

Dimension SNP (and variation):

D1: 51 706 SNP (10,6%)
D2: 17 341 SNP (3,6%)
D3:  9 758 SNP (2,0%)